Developmental xenocortication using human-derived organoids in mice - Nature

Xenocortication with human neurons enables circuit- and behaviour-level analysis of neurodevelopment in mice.

Genetically encoded cortical depletion
Emx1-cre (JAX, B6.129S2-Emx1tm1(cre)Krj/J), Esco2fl/fl (JAX, B6N.129S-Esco2tm1.1Ge/J) and C57BL SCID (JAX, B6.Cg-Prkdcscid/SzJ) mice were used to generate the …

წყარო: Nature.com